α-Conotoxin MII

Name: α-Conotoxin MII
Brand: Tocris Bioscience
SKU: 1340

Tocris Bioscience | Catalog # 1340

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Citations (10)

Product Documents

Potent and selective α3β2 and β3 nAChR antagonist

Discontinued Product

1340 has been discontinued. View all Additional Nicotinic Receptor Antagonists products.

Product Description
Licensing Information
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent and selective α3β2 and β3 nAChR antagonist

View all Additional Nicotinic Receptor Antagonists »

Product Description

α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC₅₀ = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.

Licensing Information

Sold under license from the University of Utah.

Product Specifications for α-Conotoxin MII

Molecular Weight

1710.99

Formula

C₆₇H₁₀₃N₂₃O₂₂S₄

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

175735-93-0

PubChem ID

57340508

InChI Key

DUQYFGMBLOPGBY-XCQLYXDWSA-N

SMILES

[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC2=O)C(N)=O)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

David Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur.J.Neurosci. 2010 PMID: 20377613
Harvey Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors. Mol.Pharmacol. 1997 PMID: 9203640
McIntosh Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function. Eur.J.Pharmacol. 2000 PMID: 10771014
Cartier A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J.Biol.Chem. 1996 PMID: 8631783

Product Documents for α-Conotoxin MII

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for α-Conotoxin MII

For research use only

Related Research Areas

The Cholinergic System in Alzheimer's Disease

Citations for α-Conotoxin MII

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