α-Conotoxin PnIA
Discontinued Product
3123 has been discontinued.
View all Additional Nicotinic Receptor Antagonists products.
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Description: Selective α3β2 nAChR antagonist
Biological Activity
α-Conotoxin PnIA is a selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).Technical Data
M.Wt:
1622.82
Formula:
C65H95N19O22S4
Sequence:
GCCSLPPCAANNPDYC
(Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)
Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
705300-84-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold under license from University of Utah
Background References
-
New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors.
Fainzilber et al.
Biochemistry, 1994;33:9523 -
Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity.
Luo et al.
Biochemistry, 1999;38:14542 -
Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors.
Everhart et al.
J.Pharmacol.Exp.Ther., 2003;306:664
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