Altanserin hydrochloride

Key Product Details

Product Description

Altanserin hydrochloride is a potent and selective 5-HT_2A receptor antagonist (K_i values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT_2A, α₁, 5-HT_2C, D₂ and 5-HT_1A respectively). Centrally active following systemic administration in vivo.

Product Specifications for Altanserin hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Altanserin hydrochloride

The following data is based on the product molecular weight 447.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.16 mL	55.81 mL	111.62 mL
1 mM	2.23 mL	11.16 mL	22.32 mL
2 mM	1.12 mL	5.58 mL	11.16 mL
10 mM	0.22 mL	1.12 mL	2.23 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Sietnick Involvement of 5-HT₂ receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. J.Neural Transm. 1985 PMID: 3872342
• Kennett Evidence that 5-HT_2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 1994 PMID: 7846211
• Koenig Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur.J.Pharmacol. 1987 PMID: 2956114
• Herth Synthesis and in vitro affinities of various MDL 100907 derivatives as potential ¹⁸F-radioligands for 5-HT_2A receptor imaging with PET. Bioorg.Med.Chem. 2009 PMID: 19329329

Product Documents for Altanserin hydrochloride