AM 4113

Key Product Details

Product Description

AM 4113 is a high affinity and selective CB₁ antagonist (K_d = 0.89 nM). Exhibits 100-fold selectivity for CB₁ over CB₂. Attenuates CB₁ agonist AM 411-induced locomotor suppression and reduces food intake in vivo, but does not induce signs of nausea.

Product Specifications for AM 4113

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AM 4113

The following data is based on the product molecular weight 380.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.14 mL	65.68 mL	131.35 mL
1 mM	2.63 mL	13.14 mL	26.27 mL
2 mM	1.31 mL	6.57 mL	13.14 mL
10 mM	0.26 mL	1.31 mL	2.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Hodge The cannabinoid CB₁ receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats Behav. Brain Res. 2008 PMID: 18602425
• Sink The novel cannabinoid CB₁ receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology 2008 PMID: 17581535

Product Documents for AM 4113