AMN 082 dihydrochloride

Tocris Bioscience | Catalog # 2385

Selective mGlu7 agonist
Tocris Bioscience

Key Product Details

Description

Selective mGlu7 agonist
View all Group III mGluR Agonists »

Product Description

AMN 082 dihydrochloride is a the first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.

View important information regarding the usage of AMN 082 dihydrochloride.

Product Specifications for AMN 082 dihydrochloride

Molecular Weight

465.45

Formula

C28H28N2.2HCl

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

Chemical Name

N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride

CAS Number

97075-46-2

PubChem ID

11698390

InChI Key

YRQCDCNQANSUPB-UHFFFAOYSA-N

SMILES

Cl.Cl.C(CNC(C1=CC=CC=C1)C1=CC=CC=C1)NC(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 0.93 2 with gentle warming
DMSO 46.55 100

Preparing Stock Solutions for AMN 082 dihydrochloride

The following data is based on the product molecular weight 465.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.30 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for AMN 082 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMN 082 dihydrochloride

For research use only

Citations for AMN 082 dihydrochloride

Customer Reviews for AMN 082 dihydrochloride (1)

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  • Test of potential modulation of 5HT-1B receptor effects
    Name: Sergiy Sylantyev
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Arcuate nucleus
    Verified Customer | Posted 12/10/2023
    AMN 082 was used to test a (potential) impact of metabotropic glutamate receptors on the effect of 5HT-1B receptors on neurotransmitter vesicle release in interneuronal synapse. Picture: membrane capacitance fluctuation of living neuron after series of electrical stimuli delivered to acute neural tissue. Left: control. Right: activation of metabotropic glutamate receptors (with 1 μM CHPG, 1 μM (RS)-3,5-DHPG and 1 μM AMN 082), GABA-B receptors and ACh receptors does not show a significant effect. Grey traces: individual recordings; red: averaged trace.
    AMN 082 dihydrochloride 2385

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