ANA 12

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ANA 12 | CAS No. 219766-25-3 | Trk Receptor Antagonists
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Description: TrkB receptor antagonist

Chemical Name: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide

Purity: ≥99%

Product Details
Citations (15)
Supplemental Products

Biological Activity

ANA 12 is a TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ANA 12

The citations listed below are publications that use Tocris products. Selected citations for ANA 12 include:

15 Citations: Showing 1 - 10

  1. Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.
    Authors: Vicente Et al.
    Int J Mol Sci  2022;23
  2. Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation.
    Authors: Marisela Et al.
    J Neurosci Res  2021;99:2134-2155
  3. Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement.
    Authors: Nury Et al.
    Sci Adv  2020;6:eaaz9691
  4. Prolonged Use of NMDAR Antagonist Develops Analgesic Tolerance in Neuropathic Pain via Nitric Oxide Reduction-Induced GABAergic Disinhibition.
    Authors: Jun Et al.
    Neurotherapeutics  2020;17:1016-1030
  5. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain.
    Authors: Zhou Et al.
    Cell Rep  2019;27:3844
  6. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
    Authors: Livingstone Et al.
    Front Mol Neurosci  2019;12:198
  7. Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling.
    Authors: Bernhard Et al.
    Neuron  2018;99:720-735.e6
  8. 7,8,3'-Trihydroxyflavone ameliorate oxidative stress in vivo and promotes neurite regeneration in vitro in rat retinal ganglion cells.
    Authors: Han Et al.
    Eur.J.Pharmacol.  2018;823:283
  9. The 3' UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor.
    Authors: O'Neill Et al.
    Front Cell Neurosci  2018;12:60
  10. Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats.
    Authors: Hang Et al.
    J Neurophysiol  2018;120:1307-1317


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