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Angiopep-2

Catalog #: 8828 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8828/1
Angiopep-2
1 Image
Description: Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Purity: ≥95%

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Biological Activity

Angiopep-2 is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present both on blood-brain barrier (BBB) and tumor cell membranes. Angiopep-2 binding to LRP1 facilitates receptor-mediated transcytosis of cargo across the BBB. Transcytosis-inducing molecular degraders of extracellular proteins (TransMoDEs), containing Angiopep-2 and modified to include a small-molecule ligand, induce target internalization that can cross the BBB in a variety of cell types.

Technical Data

M.Wt:
2301.5
Formula:
C104H149N29O31
Sequence:
TFFYGGSRGKRNNFKTEEY
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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