AP 1867 PEG3 Haloalkane

Key Product Details

Product Description

AP 1867 PEG3 Haloalkane is a heterobifunctional molecule inducing proximity between a Ser/Thr phosphatase (PP2) fused with FKBP12 (F36V) and a phosphosubstrate (PDCD4 and FOXO3a) fused with haloalkane dehalogenase and affecting dephosphorylation of the latter (PhosTAC). In pulldown experiments, AP 1867 PEG3 Haloalkane induces 50% dephosphorylation of PDCD4 at 10μM after 12 h incubation. Targeted protein dephosphorylation with AP 1867 PEG3 Haloalkane can be used to induce dephosphorylation of other haloalkane dehalogenase labeled phosphoproteins.

Product Specifications for AP 1867 PEG3 Haloalkane

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AP 1867 PEG3 Haloalkane

The following data is based on the product molecular weight 943.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.06 mL	5.30 mL	10.60 mL
5 mM	0.21 mL	1.06 mL	2.12 mL
10 mM	0.11 mL	0.53 mL	1.06 mL
50 mM	0.02 mL	0.11 mL	0.21 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chen Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs) ACS Chem.Biol. 2021 PMID: 34780684

Product Documents for AP 1867 PEG3 Haloalkane