AP 1867

Key Product Details

Product Description

AP 1867 is a selective binding ligand for the single point mutant of FKBP12^F36V (IC₅₀ = 1.8 nM). Functionalized with a carboxylic acid group at the meta-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with the compound's binding ability.

Product Specifications for AP 1867

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AP 1867

The following data is based on the product molecular weight 693.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.44 mL	7.21 mL	14.41 mL
5 mM	0.29 mL	1.44 mL	2.88 mL
10 mM	0.14 mL	0.72 mL	1.44 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Clackson Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9724721
• Koide A synthetic library of cell-permeable molecules. J.Am.Chem.Soc. 2001 PMID: 11456541

Product Documents for AP 1867