AP 18

Key Product Details

Product Description

AP 18 is a reversible TRPA1 channel blocker (IC₅₀ values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnamaldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC₅₀ = 10.3 μM for the inhibition of Yo-Pro uptake).

Product Specifications for AP 18

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AP 18

The following data is based on the product molecular weight 209.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.77 mL	23.85 mL	47.69 mL
5 mM	0.95 mL	4.77 mL	9.54 mL
10 mM	0.48 mL	2.38 mL	4.77 mL
50 mM	0.10 mL	0.48 mL	0.95 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

• Chen Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol.Pain 2009 PMID: 19159452
• Taylor-Clark Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol.Pharmacol. 2009 PMID: 19171673
• Petrus A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 2007 PMID: 18086313

Product Documents for AP 18