AP 811

Tocris Bioscience | Catalog # 5498

High affinity, selective NPR3 antagonist
Tocris Bioscience

Key Product Details

Description

High affinity, selective NPR3 antagonist
View all Natriuretic Peptide Receptor Antagonists »

Product Description

AP 811 is a high affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.

Product Specifications for AP 811

Molecular Weight

915.10

Formula

C46H66N12O8

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

124833-45-0

PubChem ID

44301714

InChI Key

UNMJSSQZDQBGDS-OCFLPWLCSA-N

SMILES

CC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1=CC=C(NC(=O)C2=CC3=C(C=CC=C3)C=C2)C=C1)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for AP 811

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AP 811

For research use only

Customer Reviews for AP 811 (1)

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  • Good NPR3 agonist
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 07/12/2018
    AP811 is extremely unstable. Shipped at RT as powder, but need to be frozen upon arrival and made fresh each time.
    Investigation of NPR3 agonism in blood vessels.

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