AR-A 014418

Key Product Details

Product Description

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for AR-A 014418

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AR-A 014418

The following data is based on the product molecular weight 308.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.22 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Bhat Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 2003 PMID: 12928438
• Gould AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 2004 PMID: 15315719
• Bhat and Budd GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 2002 PMID: 12566926

Product Documents for AR-A 014418