AR-M 1896

Name: AR-M 1896
Brand: Tocris Bioscience
SKU: 2699

Tocris Bioscience | Catalog # 2699

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Citations (7)

Product Documents

GAL2 agonist

Discontinued Product

2699 has been discontinued. View all Galanin Receptor Agonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

GAL2 agonist

Alternative Names

Gal(2-11)amide

View all Galanin Receptor Agonists »

Product Description

Selective galanin GAL₂ receptor agonist (IC₅₀ values are 1.76 and 879 nM for GAL₂ and GAL₁ respectively). Also shows moderate affinity for GAL₃ receptors (K_i values are 88 and 271 nM for GAL₂ and GAL₃ respectively). Antiepileptogenic agent; prevents full seizures and postkindling increases in hippocampal excitability.

Product Specifications for AR-M 1896

Molecular Weight

1136.31

Formula

C₅₄H₈₁N₁₃O₁₄

Storage

Desiccate at -20°C

CAS Number

367518-31-8

PubChem ID

6324638

InChI Key

SUJPPMXJCZETOA-ZKEPBWIVSA-N

SMILES

[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 20% formic acid

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Mazarati Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 2006 PMID: 16699066
Liu Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc.Natl.Acad.Sci USA
Lu Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides 2005 PMID: 15944007

Product Documents for AR-M 1896

Certificate of Analysis

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Product Specific Notices for AR-M 1896

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Citations for AR-M 1896

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