Argatroban

Key Product Details

Product Description

Argatroban is a potent inhibitor of thrombin mediated fibrinogen cleavage (K_i = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.

This compound is a mixture of 2 diastereomers (approximate ratio 65/35).

Product Specifications for Argatroban

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Argatroban

The following data is based on the product molecular weight 508.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.83 mL	19.66 mL
5 mM	0.39 mL	1.97 mL	3.93 mL
10 mM	0.20 mL	0.98 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Jang Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 1990 PMID: 2297828
• Fitzgerald and Fitzgerald Role of thrombin and thromboxane A₂ in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA
• Kikumoto Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 1984 PMID: 6691968

Product Documents for Argatroban