ARN 14494

Key Product Details

Product Description

ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC₅₀ = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

Product Specifications for ARN 14494

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ARN 14494

The following data is based on the product molecular weight 424.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.71 mL	23.55 mL	47.11 mL
2.5 mM	0.94 mL	4.71 mL	9.42 mL
5 mM	0.47 mL	2.36 mL	4.71 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• De Vita Inhibition of serine palmitoyltransferase by a small organic molecule promotes neuronal survival after astrocyte amyloid beta 1-42 injury. ACS Chem.Neurosci. 2019 PMID: 30481470

Product Documents for ARN 14494