ARN 14686

Key Product Details

Product Description

ARN 14686 is a NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. Can be used to detect NAAA in cell lysates or intact cells. Covalently binds the N-terminal cysteine of catalytically active NAAA. Detects catalytically active NAAA in inflamed rat paw in CFA model of inflammation. Potent NAAA inhibitor (IC₅₀ = 6 nM).

Product Specifications for ARN 14686

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ARN 14686

The following data is based on the product molecular weight 280.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.57 mL	17.83 mL	35.67 mL
5 mM	0.71 mL	3.57 mL	7.13 mL
10 mM	0.36 mL	1.78 mL	3.57 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Romeo Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 2015 PMID: 26102511

Product Documents for ARN 14686