Atosiban

Tocris Bioscience | Catalog # 6332

Potent oxytocin receptor antagonist
Tocris Bioscience

Key Product Details

Description

Potent oxytocin receptor antagonist
View all Oxytocin Receptor Antagonists »

Product Description

Atosiban is a potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca2+ concentration in myometrial cells in vitro (IC50 = 5 nM) Activates NF-κB and MAPK pathways in human amnion via Gαi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a rat preterm labor model.

Product Specifications for Atosiban

Molecular Weight

994.19

Formula

C43H67N11O12S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

CAS Number

90779-69-4

PubChem ID

5311010

InChI Key

VWXRQYYUEIYXCZ-OBIMUBPZSA-N

SMILES

[H][C@@]1([C@H](O)C)NC(C([C@H](CC)C)NC([C@H](NC(CCSSC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CCCN)=O)=O)NC([C@@H](NC1=O)CC(N)=O)=O)=O)CC3=CC=C(C=C3)OCC)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 50mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for Atosiban

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Atosiban

For research use only

Customer Reviews for Atosiban (1)

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  • Inhibition of oxytocin receptor
    Name: Mohammad Alqudah
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Smooth muscle
    Verified Customer | Posted 10/19/2022
    10 uM of atosiban 10 to 15 min in an organ bath to block oxytocin-induced contraction of gut smooth muscle strips
    Atosiban 6332

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