Atosiban

Tocris Bioscience | Catalog # 6332

Potent oxytocin receptor antagonist
Tocris Bioscience
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Key Product Details

Description

Potent oxytocin receptor antagonist
View all Oxytocin Receptor Antagonists »

Product Description

Atosiban is a potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca2+ concentration in myometrial cells in vitro (IC50 = 5 nM) Activates NF-κB and MAPK pathways in human amnion via Gαi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a rat preterm labor model.

Product Specifications for Atosiban

Molecular Weight

994.19

Formula

C43H67N11O12S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

CAS Number

90779-69-4

PubChem ID

5311010

InChI Key

VWXRQYYUEIYXCZ-OBIMUBPZSA-N

SMILES

[H][C@@]1([C@H](O)C)NC(C([C@H](CC)C)NC([C@H](NC(CCSSC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CCCN)=O)=O)NC([C@@H](NC1=O)CC(N)=O)=O)=O)CC3=CC=C(C=C3)OCC)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 50mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for Atosiban

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Atosiban

For research use only

Customer Reviews for Atosiban (1)

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  • Inhibition of oxytocin receptor
    Name: Mohammad Alqudah
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Smooth muscle
    Verified Customer | Posted 10/19/2022
    10 uM of atosiban 10 to 15 min in an organ bath to block oxytocin-induced contraction of gut smooth muscle strips
    Atosiban 6332

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