Auranofin

Tocris Bioscience | Catalog # 4600

Thioredoxin reductase inhibitor; induces MPT
Tocris Bioscience
Discontinued Product
4600 has been discontinued. View all Other Reductase Inhibitors products.

Key Product Details

Description

Thioredoxin reductase inhibitor; induces MPT
View all Other Reductase Inhibitors »

Product Description

Auranofin is an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations. Also inhibits SARS-CoV-2 infection in Huh7 cell line (IC50 = 1.4 μM)

Product Specifications for Auranofin

Molecular Weight

678.48

Formula

C20H34AuO9PS

Storage

Store at RT

Chemical Name

1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate

CAS Number

34031-32-8

PubChem ID

6918453

InChI Key

AUJRCFUBUPVWSZ-XTZHGVARSA-M

SMILES

CCP(CC)(CC)=[Au]S[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.85 100
Ethanol 33.92 50

Preparing Stock Solutions for Auranofin

The following data is based on the product molecular weight 678.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.37 mL 14.74 mL
5 mM 0.29 mL 1.47 mL 2.95 mL
10 mM 0.15 mL 0.74 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

Calculators

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Product Documents for Auranofin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Auranofin

For research use only

⚠ WARNING: This product can expose you to chemicals including Auranofin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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