AZ 12080282 dihydrochloride

Key Product Details

Product Description

AZ 12080282 dihydrochloride is an inhibitor of Hedgehog (Hh) signaling (IC₅₀ <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for AZ 12080282 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZ 12080282 dihydrochloride

The following data is based on the product molecular weight 457.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.93 mL	21.87 mL
5 mM	0.44 mL	2.19 mL	4.37 mL
10 mM	0.22 mL	1.09 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yang Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg.Med.Chem.Lett. 2012 PMID: 22704236

Product Documents for AZ 12080282 dihydrochloride