AZ 20

Tocris Bioscience | Catalog # 5198

Potent and selective ATR kinase inhibitor; antitumor
Tocris Bioscience

Key Product Details

Description

Potent and selective ATR kinase inhibitor; antitumor
View all ATM and ATR Kinase Inhibitors »

Product Description

AZ 20 is a potent and selective ATR kinase inhibitor (IC50 = 5 nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications for AZ 20

Molecular Weight

412.51

Formula

C21H24N4O3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole

CAS Number

1233339-22-4

PubChem ID

46244454

InChI Key

SCGCBAAYLFTIJU-CQSZACIVSA-N

SMILES

CS(C4(CC4)C1=CC(N5[C@H](C)COCC5)=NC(C2=CC=CC3=C2C=CN3)=N1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.63 50
Ethanol 4.13 10

Preparing Stock Solutions for AZ 20

The following data is based on the product molecular weight 412.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.85 mL 24.24 mL 48.48 mL
2.5 mM 0.97 mL 4.85 mL 9.70 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
25 mM 0.10 mL 0.48 mL 0.97 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

Product Documents for AZ 20

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZ 20

For research use only

Customer Reviews for AZ 20 (1)

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  • Highly stable
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: U2OS
    Verified Customer | Posted 06/22/2020
    I used short treatments with AZ20 in the presence of JQ1.
    AZ20 (2.4 μM)
    AZ 20 5198

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