AZ 3146

Key Product Details

Product Description

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC₅₀ = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca UK Ltd.

Product Specifications for AZ 3146

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZ 3146

The following data is based on the product molecular weight 452.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.95 mL	14.73 mL	29.46 mL
3.75 mM	0.59 mL	2.95 mL	5.89 mL
7.5 mM	0.29 mL	1.47 mL	2.95 mL
37.5 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 43 publications citing the usage of this product.

• Lan and Cleveland A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell.Biol. 2010 PMID: 20624898
• Maciejowski Mps1 directs the assembly of Cdc20 inhbitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J.Cell Biol. 2010 PMID: 20624902
• Hewitt Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J.Cell Biol. 2010 PMID: 20624899

Product Documents for AZ 3146