AZD 1283

Key Product Details

Product Description

AZD 1283 is a potent and high affinity P2Y₁₂ antagonist (IC₅₀ = 11 nM in radioligand competition binding assay, and 25 nM in a GTPγS binding assay). Causes a dose-dependent increase in blood flow and inhibits ADP-induced platelet aggregation in vivo. Antithrombotic.

Product Specifications for AZD 1283

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZD 1283

The following data is based on the product molecular weight 470.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.63 mL	21.25 mL
5 mM	0.43 mL	2.13 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Zhang Agonist-bound structure of the human P2Y₁₂ receptor. Nature 2014 PMID: 24784220
• Zhang Structure of the human P2Y₁₂ receptor in complex with an antithrombotic drug. Nature 2014 PMID: 24670650
• Bach Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y₁₂ receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J.Med.Chem. 2013 PMID: 23899349

Product Documents for AZD 1283