AZD 5248

Key Product Details

Product Description

AZD 5248 is a potent cathepsin C (also known as dipeptidyl peptidase 1, or DPP1) inhibitor (IC₅₀ values are 44 and 67 nM for human and rat, respectively). In vivo, AZD 5248 inhibition of cathepsin C correlates to the reduction of NSP (neutrophil serine protease) activity measured in rat bone marrow and blood. In rats, quantitative whole-body autoradiography studies demonstrate aortic binding of AZ 5248. This compound is orally bioavailable.

Product Specifications for AZD 5248

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZD 5248

The following data is based on the product molecular weight 374.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.35 mL	26.71 mL
5 mM	0.53 mL	2.67 mL	5.34 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bragg Aortic binding of AZD5248: mechanistic insight and reactivity assays to support lead optimization. Chem.Res.Toxicol. 2015 PMID: 26351880
• Furber Cathepsin C inhibitors: property optimization and identification of a clinical candidate. J.Med.Chem. 2014 PMID: 24592859
• Gardiner Neutrophil maturation rate determines the effects of dipeptidyl peptidase 1 inhibition on neutrophil serine protease activity. Br.J.Pharmacol. 2016 PMID: 27186823

Product Documents for AZD 5248