AZD 9272

Key Product Details

Product Description

AZD 9272 is a potent and selective mGlu₅ antagonist (IC₅₀ values are 2.6 and 7.6 nM for rat and human receptors, respectively). Exhibits >3900-fold selectivity for mGlu₅ over other mGlu receptors. Also selective over a panel of other targets. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.

Product Specifications for AZD 9272

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZD 9272

The following data is based on the product molecular weight 284.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.04 mL	35.18 mL	70.37 mL
2.5 mM	1.41 mL	7.04 mL	14.07 mL
5 mM	0.70 mL	3.52 mL	7.04 mL
25 mM	0.14 mL	0.70 mL	1.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Raboisson Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg.Med.Chem.Lett. 2012 PMID: 23046966
• Swedberg and Raboisson AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 2014 PMID: 24876235

Product Documents for AZD 9272