Baicalein
Chemical Name: 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Purity: ≥98%
Biological Activity
Baicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. Also inhibits erastin-induced ferroptosis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Resolvin D1 drives establishment of Leishmania amazonensis infection
H Malta-Sant, BB Andrade, DL Zanette, JM Costa, PT Bozza, C Bandeira-M, A Barral, J França-Cos, VM Borges
Sci Rep, 2017;7(0):46363. -
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules.
Hsu et al.
Eur.J.Pharmacol., 2001;425:165 -
Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.
Nakahata et al.
Eur.J.Pharmacol., 2003;461:1 -
Selective inhibition of platelet lipoxygenase by baicalein.
Sekiya and Okuda
Biochem.Biophys.Res.Commun., 1982;105:1090 -
Identification of Baicalein as a ferroptosis inhibitor by natural product library screening.
Xie et al.
Biochem.Biophys.Res.Commun., 2016;473:775 -
Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway.
Hsieh et al.
Clin.Mol.Allergy, 2007;26:5
Product Datasheets
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Citations for Baicalein
The citations listed below are publications that use Tocris products. Selected citations for Baicalein include:
6 Citations: Showing 1 - 6
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The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Authors: Oguh-Olayinka Et al.
Pathol Oncol Res 2019;
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Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.
Authors: Mishra Et al.
Nat Microbiol 2017;2:17072
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12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.
Authors: Maskrey Et al.
PLoS One 2014;11:33
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Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.
Authors: Potapova Et al.
PLoS One 2013;8:e73929
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Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.
Authors: Starowicz Et al.
PLoS One 2013;8:e60040
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TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Authors: Gibson Et al.
Neuron 2008;57:746
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