BAK Antibody Blocking Peptide

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Product Specifications

Formulation, Preparation, and Storage

Background: BAK

Bak a pro-apoptotic analog to Bax, is a member of the Bcl-2 family of proteins. During mitochondria-regulated programmed cell death, Bak promotes apoptosis by binding Bcl-2 and inhibiting its anti-apoptotic function (1). Upon apoptotic stimulation, Bak translocates from the cytosol to the mitochondrial membrane (2). Pro-apoptotic cascade activates BID, which oligomerizes Bak into pores that result in the release of cytochrome c (2, 3). In healthy cells, Bak associate with Bcl-xL and Mcl-1 but not with Bcl-2, Bcl-w or A1 and only when freed of both Bak will induce apoptosis.

Additional BAK Products

• All Products for BAK
• BAK ELISA Kits
• BAK Lysates
• BAK Primary Antibodies
• BAK Proteins and Enzymes

Product Documents for BAK Antibody Blocking Peptide