BAY 091

Key Product Details

Product Description

BAY 091 is a potent and selective, ATP-dependent, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) inhibitor (IC₅₀ values are 1.3 nM, 8.5 nM and 16.4 nM with 10 μM ATP, or in an HTRF assay with 10 μM and 2 mM ATP, respectively).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 091 probe summary on the SGC website.

Product Specifications for BAY 091

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BAY 091

The following data is based on the product molecular weight 440.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.54 mL	22.70 mL	45.41 mL
2.5 mM	0.91 mL	4.54 mL	9.08 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
25 mM	0.09 mL	0.45 mL	0.91 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wortmann Discovery and characterization of the potent and highly selective 1,7-naphthyridine-based inhibitors BAY-091 and BAY-297 of the kinase PIP4K2A. J.Med.Chem. 2021 PMID: 34699202

Product Documents for BAY 091