BAY 6035

Tocris Bioscience | Catalog # 6561

Potent and selective SMYD3 inhibitor
Tocris Bioscience
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Key Product Details

Description

Potent and selective SMYD3 inhibitor

Product Description

BAY 6035 is a potent SMYD3 inhibitor (IC50 = 70 nM for inhibition of MEKK2 methylation in cells). Exhibits >100-fold selectivity for SMYD3 over other histone methyltransferases.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-6035 probe summary on the SGC website.

Product Specifications for BAY 6035

Molecular Weight

396.48

Formula

C22H28N4O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-1-(3-Azabicyclo[3.1.0]hex-3-ylcarbonyl)-N-(2-cyclopropylethyl)-2,3,4,5-tetrahydro-2-methyl-4-oxo-1H-1,5-benzodiazepine-7-carboxamide

CAS Number

2247890-13-5

PubChem ID

137499231

InChI Key

CKFRXCBNKKOFGO-IGEOTXOUSA-N

SMILES

O=C(NCCC1CC1)C2=CC=C3N([C@H](CC(NC3=C2)=O)C)C(N4CC5CC5C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.65 100
Ethanol 39.65 100

Preparing Stock Solutions for BAY 6035

The following data is based on the product molecular weight 396.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.50 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

There are currently no references for this product.

Product Documents for BAY 6035

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BAY 6035

For research use only

Related Research Areas

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