BAY 826

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BAY 826 | CAS No. 1448316-08-2 | Additional RTK Inhibitors
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Description: Potent Tie2 inhibitor

Chemical Name: [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

BAY 826 is a potent Tie 2 inhibitor (IC50 = 1.3 nM for autophosphorylation of Tie2 in HUVECs), which is selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. BAY 826 displays in vivo efficacy in some murine glioma models.

Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.

External Portal Information is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 826 is reviewed on the chemical probes website.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-826 probe summary on the SGC website.

Product Datasheets

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Citation for BAY 826

The citations listed below are publications that use Tocris products. Selected citations for BAY 826 include:

1 Citation: Showing 1 - 1


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