BAY 9835

Key Product Details

Product Description

BAY 9835 is a potent ADAMTS7 and ADAMTS12 inhibitor (IC₅₀ values are 6 nM and 30 nM, respectively). BAY 9835 is selective over other metalloproteases (ADAMTS4, ADAMTS5, ADAM8, ADAM10, ADAM17, MMP2, MMP12, MMP14, MMP15). BAY 9835 is the first orally bioavailable ADAMTS7 inhibitor.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 9835 probe summary on the SGC website.

Product Specifications for BAY 9835

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BAY 9835

The following data is based on the product molecular weight 493.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.13 mL	20.27 mL
5 mM	0.41 mL	2.03 mL	4.05 mL
10 mM	0.20 mL	1.01 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Meibom BAY-9835: Discovery of the first orally bioavailable ADAMTS7 inhibitor. J.Med.Chem. 2024 PMID: 38348661

Product Documents for BAY 9835