BAY-X 1005

Key Product Details

Product Description

BAY-X 1005 is a 5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B₄ and C₄ in animal models; inhibits synthesis of leukotriene B₄ in A23187-stimulated leukocytes (IC₅₀ values are 0.026, 0.039 and 0.22 μM for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active.

Product Specifications for BAY-X 1005

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BAY-X 1005

The following data is based on the product molecular weight 361.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.83 mL	27.67 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hatzelmann Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 1994 PMID: 7741044
• Fruchtmann In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. Agents Actions 1993 PMID: 8213345
• Muller-Peddinghaus BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J.Pharmacol.Exp.Ther. 1993 PMID: 8229782

Product Documents for BAY-X 1005