BBI 2779

Tocris Bioscience | Catalog # 8955

Potent and selective CHK1 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective CHK1 inhibitor
View all Checkpoint Control Kinase Inhibitors »

Product Description

BBI 2779 is a potent and selective checkpoint kinase 1 (CHK1) inhibitor (IC50 = 0.5 nM).

It displays 160-fold selectivity over CHK2. BBI 2779 preferentially kills ecDNA-containing tumour cells (IC50 = 3 nM).

In a gastric cancer model containing FGFR2 amplified on ecDNA, BBI 2779 suppresses tumour growth and prevents ecDNA-mediated acquired resistance to the pan-FGFR inhibitor infigratinib, resulting in potent and sustained tumour regression in mice.

BBI 2779 is orally bioavailable.

Licensing Information

Sold with kind permission of Boundless Bio

Product Specifications for BBI 2779

Molecular Weight

423.43

Formula

C19H19N7O2.HCO2H

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-[[5-[2-[[(1R,2R)-2-Aminocyclobutyl]oxy]-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile formate

InChI Key

GEFZCFXMQCSJAM-QMDUSEKHSA-N

SMILES

N[C@H](CC1)[C@@H]1OC2=C(C3=CC(NC4=NC=C(C#N)N=C4)=NN3)C(OC)=CC=C2.O=CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.34 100

Preparing Stock Solutions for BBI 2779

The following data is based on the product molecular weight 423.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.81 mL 23.62 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BBI 2779

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BBI 2779

For research use only

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