Chemical Name: (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid
Biological ActivityBetulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%). Betulinic acid suppresses areobic glycolysis by regulating the Cav-1/NF-κB/c-Myc pathway in and inhibits growth in breast cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Genet et al.
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
Kashiwada et al.
Betulinic acid for cancer treatment and prevention.
Citations for Betulinic acid
The citations listed below are publications that use Tocris products. Selected citations for Betulinic acid include:
2 Citations: Showing 1 - 2
MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization.
Authors: Qing Et al.
Sci Rep 2022;12:4183
Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.
Authors: Inoue Et al.
Neurotox Res 2012;303:G810
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