BGC 20-761

Key Product Details

Product Description

BGC 20-761 is a selective, high affinity 5-HT₆ antagonist (K_i = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.

Product Specifications for BGC 20-761

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BGC 20-761

The following data is based on the product molecular weight 294.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	16.98 mL	33.97 mL
5 mM	0.68 mL	3.40 mL	6.79 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mitchell BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 2006 PMID: 16298400
• Glennon 2-substituted tryptamines: agents with selectivity for 5-HT₆ serotonin receptors. J.Med.Chem. 2000 PMID: 10715164

Product Documents for BGC 20-761