BI 3231

Key Product Details

Product Description

BI 3231 is a potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor (IC₅₀ values are 1 nM and 13 nM at hHSD17B13 and mHSD17B13 respectively; K_i = 0.7 nM). Reduces palmitic acid-induced toxicity in hepatocytes. Suitable for use in vivo and in vitro.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 3231 probe summary on the SGC website.

Product Specifications for BI 3231

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BI 3231

The following data is based on the product molecular weight 380.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.45 mL	262.90 mL
0.5 mM	5.26 mL	26.29 mL	52.58 mL
1 mM	2.63 mL	13.15 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Thamm Discovery of a novel potent and selective HSD17B13 inhibitor, BI-3231, a well-characterized chemical probe available for open science. J.Med.Chem. 2023 PMID: 36727857

Product Documents for BI 3231