BI 9564

Key Product Details

Product Description

BI 9564 is a potent and selective BRD9 and BRD7 inhibitor (K_d values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9564 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI-9564 is reviewed on the chemical probes website.

Product Specifications for BI 9564

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BI 9564

The following data is based on the product molecular weight 353.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.15 mL	70.74 mL	141.48 mL
1 mM	2.83 mL	14.15 mL	28.30 mL
2 mM	1.41 mL	7.07 mL	14.15 mL
10 mM	0.28 mL	1.41 mL	2.83 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Karim and Schönbrunn An Advanced Tool To Interrogate BRD9. J.Med.Chem. 2016 PMID: 27120693
• Martin Structure-based design of an in vivo active selective BRD9 inhibitor J.Med.Chem. 2016 PMID: 26914985

Product Documents for BI 9564