Bicalutamide

Tocris Bioscience | Catalog # 3389

Non-steroidal androgen receptor antagonist
Tocris Bioscience
Discontinued Product
3389 has been discontinued. View all Androgen Receptor Antagonists products.

Key Product Details

Description

Non-steroidal androgen receptor antagonist

Alternative Names

Casodex,ICI 176,334
View all Androgen Receptor Antagonists »

Product Description

Bicalutamide is an orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca

Product Specifications for Bicalutamide

Molecular Weight

430.37

Formula

C18H14F4N2O4S

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

CAS Number

90357-06-5

PubChem ID

2375

InChI Key

LKJPYSCBVHEWIU-UHFFFAOYSA-N

SMILES

O=C(C(O)(C)CS(C2=CC=C(F)C=C2)(=O)=O)NC1=CC(C(F)(F)F)=C(C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.04 100
Ethanol 4.3 10

Preparing Stock Solutions for Bicalutamide

The following data is based on the product molecular weight 430.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.62 mL 23.24 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for Bicalutamide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Bicalutamide

For research use only

Customer Reviews for Bicalutamide (1)

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  • In vitro culture with c4-2 cells to induce AR reduction
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: c4-2 cell
    Verified Customer | Posted 11/03/2019
    in vitro culture with c4-2 cells to induce AR reduction
    Bicalutamide 3389

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