BIMU 8

Key Product Details

Product Description

BIMU 8 is a potent 5-HT₄ receptor full agonist (K_D = 77 nM and EC₅₀ = 18 nM for wild type 5-HT₄ receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.

Product Specifications for BIMU 8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BIMU 8

The following data is based on the product molecular weight 378.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.20 mL	26.39 mL
5 mM	0.53 mL	2.64 mL	5.28 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

• Schaus Synthesis and structure-activity relationships of potent and orally active 5-HT₄ receptor antagonists: Indazole and benzimidazoline derivatives. J.Med.Chem. 1998 PMID: 9599243
• Pellissier Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol.Pharmacol. 2009 PMID: 19168624

Product Documents for BIMU 8