BIO 5192

Tocris Bioscience | Catalog # 5051

Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
Tocris Bioscience

Key Product Details

Description

Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
View all Integrin Receptor Inhibitors »

Product Description

BIO 5192 is a highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.

Product Specifications for BIO 5192

Molecular Weight

817.78

Formula

C38H46Cl2N6O8S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid

CAS Number

327613-57-0

PubChem ID

10350459

InChI Key

MNQBPRHHZPXCKZ-ZDCRTTOTSA-N

SMILES

O=C(NC2=CC=C(CC(N(C)[C@@H](CC(C)C)C(NCC[C@@H]([C@@](O)=O)N[C@]([C@H]3N(S(C4=CC(Cl)=CC(Cl)=C4)(=O)=O)CCC3)=O)=O)=O)C=C2)NC1=CC=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 81.78 100

Preparing Stock Solutions for BIO 5192

The following data is based on the product molecular weight 817.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.22 mL 6.11 mL 12.23 mL
5 mM 0.24 mL 1.22 mL 2.45 mL
10 mM 0.12 mL 0.61 mL 1.22 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

Product Documents for BIO 5192

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BIO 5192

For research use only

Customer Reviews for BIO 5192 (2)

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  • a4b1 conformation stabilizer
    Name: Martin Bush
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 05/10/2018
    We used this small molecule to lock a4b1 in an open conformation for EM imaging. It worked very nicely.
  • In Vivo alpha4 blockade
    Name: Anonymous
    Assay Type: In Vivo
    Cell Line/Tissue: Peripheral blood, Brain, spleen
    Verified Customer | Posted 12/22/2017
    Reconstituted in DMSO. Diluted for use in PBS. Clinical saline caused precipitation.
    BIO5192 was administered 10mg/kg daily.
    BIO 5192 5051

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