BIO-acetoxime

Key Product Details

Product Description

BIO-acetoxime is a selective GSK-3α/β inhibitor (IC₅₀ values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Product Specifications for BIO-acetoxime

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BIO-acetoxime

The following data is based on the product molecular weight 398.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.56 mL	62.78 mL	125.56 mL
1 mM	2.51 mL	12.56 mL	25.11 mL
2 mM	1.26 mL	6.28 mL	12.56 mL
10 mM	0.25 mL	1.26 mL	2.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Polychronopoulos Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 2004 PMID: 14761195
• Gattinoni Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 2009 PMID: 19525962
• Meijer GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 2003 PMID: 14700633

Product Documents for BIO-acetoxime