BIO

Key Product Details

Product Description

BIO is a potent ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC₅₀ = 5 nM). Also inhibits cyclin-dependent kinases (cdks; IC₅₀ values are in vitro; also promotes proliferation and dedifferentiation in cardiomyocytes.

Negative Control also available.

Product Specifications for BIO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BIO

The following data is based on the product molecular weight 356.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.08 mL	140.38 mL	280.76 mL
0.5 mM	5.62 mL	28.08 mL	56.15 mL
1 mM	2.81 mL	14.04 mL	28.08 mL
5 mM	0.56 mL	2.81 mL	5.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 78 publications citing the usage of this product.

• Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
• Polychronopoulos Structural basis for the synthesis of indirubins as potent and selective inhibtors of glycogen synthase kinase-3 and cyclin dependent kinases. J.Med.Chem. 2004 PMID: 14761195
• Tseng The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem.Biol. 2006 PMID: 16984885
• Meijer GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 2003 PMID: 14700633

Product Documents for BIO