BL 1249

Tocris Bioscience | Catalog # 3797

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
Tocris Bioscience

Key Product Details

Description

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
View all Two-P Potassium Channels Activators »

Product Description

BL 1249 is a K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel opener (EC50 values are 5.5 μM and 8 μM, respectively). Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).

Product Specifications for BL 1249

Molecular Weight

291.35

Formula

C17H17N5

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine

CAS Number

18200-13-0

PubChem ID

16078951

InChI Key

YYNRZIFBTOUICE-UHFFFAOYSA-N

SMILES

C1(NC3=CC=CC4=C3CCCC4)=CC=CC=C1C2=NN=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.14 100
1eq. NaOH 29.14 100

Preparing Stock Solutions for BL 1249

The following data is based on the product molecular weight 291.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.16 mL 34.32 mL
5 mM 0.69 mL 3.43 mL 6.86 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for BL 1249

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BL 1249

For research use only

Customer Reviews for BL 1249 (1)

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  • BL 1249 performed ideally on biology lab conditions
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/31/2018
    The product dissolved in DMSO must be handled carefully as it easily crosses cell membrane.
    Great potassium channel activator. Was studied on potassium channel expressed on human brain cells. The product performed well under experimental conditions and would purchase again.
    BL 1249 3797

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