BMS 303141

Tocris Bioscience | Catalog # 4609

ATP citrate lyase inhibitor; orally bioavailable
Tocris Bioscience

Key Product Details

Description

ATP citrate lyase inhibitor; orally bioavailable
View all ATP Citrate Lyase Inhibitors »

Product Description

BMS 303141 is an ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia; reduces cell proliferation in HepG2 and Huh-7 cell lines and in PD-1 deficient lymphomas. Orally bioavailable.

Product Specifications for BMS 303141

Molecular Weight

424.30

Formula

C19H15Cl2NO4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide

CAS Number

943962-47-8

PubChem ID

90488956

InChI Key

LIZVMVYXZWADCK-UHFFFAOYSA-N

SMILES

ClC1=CC(Cl)=C(O)C=C1S(NC2=C(C3=CC=CC=C3)C=CC(OC)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.24 10
Ethanol 21.21 50

Preparing Stock Solutions for BMS 303141

The following data is based on the product molecular weight 424.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.71 mL 23.57 mL 47.14 mL
2.5 mM 0.94 mL 4.71 mL 9.43 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

Product Documents for BMS 303141

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMS 303141

For research use only

Customer Reviews for BMS 303141

There are currently no reviews for this product. Be the first to review BMS 303141 and earn rewards!

Have you used BMS 303141?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card