BMS 345541

Tocris Bioscience | Catalog # 4806

Selective allosteric inhibitor of IKK; anti-inflammatory
Tocris Bioscience

Key Product Details

Description

Selective allosteric inhibitor of IKK; anti-inflammatory
View all IkB Kinase Inhibitors »

Product Description

BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

Product Specifications for BMS 345541

Molecular Weight

291.78

Formula

C14H17N5.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

CAS Number

547757-23-3

PubChem ID

9926054

InChI Key

MIDKPVLYXNLFGZ-UHFFFAOYSA-N

SMILES

NCCNC1=NC3=C(C=C(C)C=C3)N2C1=NC=C2C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.18 100
DMSO 29.18 100

Preparing Stock Solutions for BMS 345541

The following data is based on the product molecular weight 291.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.14 mL 34.27 mL
5 mM 0.69 mL 3.43 mL 6.85 mL
10 mM 0.34 mL 1.71 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Documents for BMS 345541

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMS 345541

For research use only

Customer Reviews for BMS 345541 (2)

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  • BMS 345541 (Cat. No. 4806) in 3 D cultures
    Name: Clara Lubeseder-Martellato
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Acini
    Verified Customer | Posted 11/12/2021
    BMS 345541 was added to pancreatic acinar 3-dimensional cultures and differentiation of the cultures was monitored for 3 to 4 days. The concentration ranged between 1 and 10 uM.
  • Great, easy to store
    Name: Brian Englar
    Species: Human
    Assay Type: Ex Vivo
    Cell Line/Tissue: MDA-231
    Verified Customer | Posted 02/06/2019
    This IKK inhibitor worked in our evaluation of TAK1 in MDA-231 cells. We compared the ability of this inhibitor to induce TNf mediated death to a TAK1 inhibitor.
    BMS 345541 4806

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