BMS 466442

Key Product Details

Product Description

BMS 466442 is a potent and selective asc-1 (alanine-serine-cysteine-1) transporter inhibitor (IC₅₀ values are 20 and 37 nM in rat primary cortical cultures and HEK cells expressing asc-1 respectively). Displays >1000-fold selectivity for asc-1 over LAT-2 and ASCT-2. This compound is unsuitable for in vivo studies.

Product Specifications for BMS 466442

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMS 466442

The following data is based on the product molecular weight 538.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.28 mL	18.57 mL
5 mM	0.37 mL	1.86 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Brown In vitro characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J.Neurochem. 2014 PMID: 24266811
• Torrecillas Inhibition of the alanine-serine-cysteine-1 transporter by BMS-466442. ACS Chem.Neurosci. 2019 PMID: 30821959

Product Documents for BMS 466442