BMS 509744

Key Product Details

Product Description

BMS 509744 is a potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitor (IC₅₀ = 19 nM). Displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. Reduces HIV infection of primary CD4⁺ T cells and attenuates the establishment of HIV infection in vitro. Reduces T cell proliferation and IL-2 production in vitro. Reduces lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.

Product Specifications for BMS 509744

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMS 509744

The following data is based on the product molecular weight 623.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.60 mL	8.02 mL	16.03 mL
5 mM	0.32 mL	1.60 mL	3.21 mL
10 mM	0.16 mL	0.80 mL	1.60 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Das Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg.Med.Chem.Lett. 2006 PMID: 16682193
• Readinger Selective targeting of ITK blocks multiple steps of HIV replication. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 18443296
• Kutach Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation. Chem Biol Drug Des. 2010 PMID: 20545945

Product Documents for BMS 509744