BMS 566419

Key Product Details

Product Description

BMS 566419 is a potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC₅₀ = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Product Specifications for BMS 566419

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMS 566419

The following data is based on the product molecular weight 487.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.25 mL	20.51 mL
5 mM	0.41 mL	2.05 mL	4.10 mL
10 mM	0.21 mL	1.03 mL	2.05 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Watterson Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 2007 PMID: 17585753

Product Documents for BMS 566419