Bobcat339

Key Product Details

Product Description

Bobcat339 is a selective cytosine-based inhibitor of ten-eleven translocation methylcytosine dioxygenase (TET) (IC₅₀ values are 33 and 73 μM for TET1 and TET2, respectively). Bobcat339 reduces DNA 5-hydroxymethylcytosine (5hmC) levels in cells without inhibiting the DNA methyltransferase DNMT3a.

Product Specifications for Bobcat339

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Bobcat339

The following data is based on the product molecular weight 297.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.36 mL	16.79 mL	33.59 mL
5 mM	0.67 mL	3.36 mL	6.72 mL
10 mM	0.34 mL	1.68 mL	3.36 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Blecua The DNA methylation landscape of hematological malignancies: an update. Mol.Oncol. 2020 PMID: 32526054
• Chua Cytosine-based TET enzyme inhibitors. ACS Med.Chem.Lett. 2019 PMID: 30783500

Product Documents for Bobcat339