BPTU

Key Product Details

Product Description

BPTU is an allosteric antagonist of P2Y₁ (EC₅₀ = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced by electrical field stimulation, nicotine and P2Y agonists. Antithrombotic; reduces platelet aggregation.

Product Specifications for BPTU

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BPTU

The following data is based on the product molecular weight 445.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.23 mL	22.45 mL
5 mM	0.45 mL	2.25 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.25 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Zhang Two disparate ligand-binding sites in the human P2Y1 receptor. Nature. 2015 PMID: 25822790
• Mañé BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. Neuropharmacology. 2016 PMID: 27496690
• Chao Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. J.Med.Chem. 2013 PMID: 23368907

Product Documents for BPTU