BRD 4770

Tocris Bioscience | Catalog # 6282

G9a inhibitor and S-adenosyl methionine mimetic; cell permeable
Tocris Bioscience
Discontinued Product
6282 has been discontinued. View all G9a/GLP Inhibitor products.

Key Product Details

Description

G9a inhibitor and S-adenosyl methionine mimetic; cell permeable
View all G9a/GLP Inhibitor »

Product Description

BRD 4770 is a G9a inhibitor and S-adenosyl methionine (SAM) mimetic. Inhibits methylation of H3K9 (EC50 ~ 5 μM) and induces senescence in PANC-1 cells. Induces ATM activation without DNA damage. Cell permeable.

Product Specifications for BRD 4770

Molecular Weight

413.47

Formula

C25H23N3O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate

CAS Number

1374601-40-7

PubChem ID

72193870

InChI Key

UCGWYCMPZXDHNR-UHFFFAOYSA-N

SMILES

COC(C1=CC=C2N(C(NC(C3=CC=CC=C3)=O)=NC2=C1)CCCC4=CC=CC=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.27 20

Preparing Stock Solutions for BRD 4770

The following data is based on the product molecular weight 413.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.09 mL 60.46 mL 120.93 mL
1 mM 2.42 mL 12.09 mL 24.19 mL
2 mM 1.21 mL 6.05 mL 12.09 mL
10 mM 0.24 mL 1.21 mL 2.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BRD 4770

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BRD 4770

For research use only

Related Research Areas

Epigenetics
Notch Pathway

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